New Step by Step Map For cees dekker
New Step by Step Map For cees dekker
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Human Rad51 filaments on double- and solitary-stranded DNA: correlating regular and irregular kinds with recombination function.
[Laughs] ‘It was certainly an excellent risk! At the time, I had been very well informed that it could go Erroneous Which I could grow to be much less successful, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And fortuitously all of it worked out.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
That could be a desire of mine and we set to work which has a tasty dose of naivety. This is certainly something that will probably generate spectacular leads to the extended phrase, but that doesn't make any difference. You should not only want to work to the questions of tomorrow, but in addition over the concerns on the working day just after tomorrow.’
Our investigation ranges through the biophysics of DNA to artificial cells and over and above. Remember to have a look beneath in the spectrum of our present tasks.
‘At the beginning we looked at biological https://www.ceesdekker.net programs with a physical look at and acted on The premise of the equipment we understood. It took a number of years before we started out Performing more on the big biological concerns. I then began to connect with it nanobiology, a term that did not exist at time.
2011, 1st in vitro measurements of transport across a single biomimetic nuclear pore complex; development of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination
‘Certainly, I realize people today had been amazed at the time. At the end of the nineties, Once i was in my forties, I had been Professor of Molecular Electronics and I have to admit that it experienced turn into a bit bored, I didn’t understand A great deal any more. The sector went additional into the application side, how you could possibly combine nanotubes into electronic circuits.
Resolving the step size in condensin-pushed DNA loop extrusion identifies ATP binding given that the move-building system
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
2006, first demonstration of molecular sorting within a lab over a chip applying biomotors; discovery of nanobubbles in strong-condition nanopores; and first estimate of electrokinetic Vitality conversion in a very nanofluidic channel
2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of very long-variety conformational improvements in Mre11/DNA restore complexes; and initially force measurements on the DNA molecule inside of a nanopore
It had been an exceedingly fascinating time, for the duration of which I been given lots of assist from Delft College of Technologies, in which I had been a professor at the time, and I started out various collaborations with molecular biologists. That served me learn a whole lot.’